HealGen is a series of products independently developed by Bestzyme with a new glycoside hydrolase -- muramidase as the core, which can timely clean up the bacteria metabolized by microorganisms in the intestinal tract, optimize the intestinal environment, help intestinal villi to absorb nutrients, and improve the utilization rate of feed nutrients. At the same time, the enzyme hydrolysate cytoplasmic dipeptide has an immune-enhancing effect. Bidirectional enhancement of humoral immunity and cellular immunity is a new enzyme preparation product focusing on intestinal nutrition and body health.
The main component muramase can enzymatically hydrolyze the β-1.4 glycosidic bond between the cell wall peptidoglycan chain N-acetylmuramic acid and N-acetylglucosamine to destroy the bacterial cell wall. Remove bacterial fragments attached to the intestine, clean up the intestinal environment, enhance the absorption of nutrients by the intestinal mucosa, and further unlock intestinal nutrition.
Degradation of peptidoglycan produces muramyl dipeptide (MDP), which acts as an immune adjuvant, activates the intracellular pattern recognition receptor NOD2, activates the downstream transcription factor-kB, and regulates immune defense responses and inflammatory responses.
Purify the intestinal environment, promote nutrient absorption, improve the digestion and utilization rate of feed, improve animal production performance, and increase breeding efficiency.
Target identification of harmful bacteria, and quickly form a good intestinal flora homeostasis.
Accelerate the repair and development of intestinal epithelial cells, improve the integrity of the intestinal morphology, and improve the intestinal digestion and absorption capacity.
Enhance the body's immune defense, prevent bacterial enteritis and diarrhea, improve animal immunity, and protect animal health.
HealGen can effectively clean up the broken bacteria and achieve the effect of cleaning the intestines.
Test site: Shenyang Agricultural University
Test animal: AA male broiler, 0-42d
Control: basal diet
Test 1: basal diet + 250 g/t HealGen
Test 2: basal diet + 3000 g/t HealGen
Adding 250g/t HealGen can increase EPI by 62.58, decrease F/G by 0.07, increase ADG by 3.56, and increase income by 1.08 yuan per broiler.
Income from weight gain (yuan/each)
Feed cost (yuan/each)
Increasing the height of intestinal villi in the ileum and jejunum, and reducing the depth of crypts, indicates that HealGen significantly improves the intestinal condition and enhances digestion.
HealGen significantly increases the CP metabolic rate, and also has a certain effect on the apparent metabolic rate of DM and Ca.
HealGen can effectively increase levels of IgA, IgG and IgM in the serum and immune organ index, and reduce the mortality rate.
HealGen significantly improves T-AOC, SOD and GSH-Px, reduces the level of MDA in broiler serum.
HealGen could improve the performance of broilers and reduce the negative effects of C.p.
Test site: Hunan Agricultural University
Test animal: AA male broiler, 14-28d
Test NH ：basal diet+ 60 g/t HealGen
Test C.P ：Control+ C.p challenge
Test NH+ C.p：Test NH+ C.p challenge
Challenge conditions: daily gavage of C.p suspension [1×109CFU/ (mL· only)]
Muramidase, Xylanase, Mannanase, Cellulase, Glucanase
For drinking water, it is recommended to add 30g/t of water
It is recommended to add 250g/t of complete feed
Storage and Shelf Life
Store in a dry and ventilated place, avoid high temperature storage. Shelf life is 12 months in original packaging.