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HealGen

HealGen is a series of products independently developed by Bestzyme with a new glycoside hydrolase -- muramidase as the core, which can timely clean up the bacteria metabolized by microorganisms in the intestinal tract, optimize the intestinal environment, help intestinal villi to absorb nutrients, and improve the utilization rate of feed nutrients. At the same time, the enzyme hydrolysate cytoplasmic dipeptide has an immune-enhancing effect. Bidirectional enhancement of humoral immunity and cellular immunity is a new enzyme preparation product focusing on intestinal nutrition and body health.

HealGen
HealGen
HealGen


The mechanism of action of HealGen


Nutrition Mechanism:

The main component muramase can enzymatically hydrolyze the β-1.4 glycosidic bond between the cell wall peptidoglycan chain N-acetylmuramic acid and N-acetylglucosamine to destroy the bacterial cell wall. Remove bacterial fragments attached to the intestine, clean up the intestinal environment, enhance the absorption of nutrients by the intestinal mucosa, and further unlock intestinal nutrition.


Immune mechanism:

Degradation of peptidoglycan produces muramyl dipeptide (MDP), which acts as an immune adjuvant, activates the intracellular pattern recognition receptor NOD2, activates the downstream transcription factor-kB, and regulates immune defense responses and inflammatory responses.


The effect of HealGen


  • Purify the intestinal environment, promote nutrient absorption, improve the digestion and utilization rate of feed, improve animal production performance, and increase breeding efficiency.

  • Target identification of harmful bacteria, and quickly form a good intestinal flora homeostasis.

  • Accelerate the repair and development of intestinal epithelial cells, improve the integrity of the intestinal morphology, and improve the intestinal digestion and absorption capacity.

  • Enhance the body's immune defense, prevent bacterial enteritis and diarrhea, improve animal immunity, and protect animal health.


In vitro application effect — clean up broken bacteria


HealGen can effectively clean up the broken bacteria and achieve the effect of cleaning the intestines.


HealGen


Production Benefit – Broiler


Test site: Shenyang Agricultural University

Test animal: AA male broiler, 0-42d

Test design:

Control: basal diet

Test 1: basal diet + 250 g/t HealGen

Test 2: basal diet + 3000 g/t HealGen


Adding 250g/t HealGen can increase EPI by 62.58, decrease F/G by 0.07, increase ADG by 3.56, and increase income by 1.08 yuan per broiler.


HealGen


HealGen


HealGen



0 g/t

250 g/t

ADG(kg)

2.52

2.67

Income from weight gain (yuan/each)

21.17

22.43

Feed cost (yuan/each)

12.52

12.71

Profit (yuan/each)

6.69

7.77


Breeding effect — Improve intestinal villi structure

Increasing the height of intestinal villi in the ileum and jejunum, and reducing the depth of crypts, indicates that HealGen significantly improves the intestinal condition and enhances digestion.


HealGen


Breeding effect — Improve the apparent digestibility of nutrients

HealGen significantly increases the CP metabolic rate, and also has a certain effect on the apparent metabolic rate of DM and Ca.


HealGen


Breeding effect—Improve immune globulin and organ index

HealGen can effectively increase levels of IgA, IgG and IgM in the serum and immune organ index, and reduce the mortality rate.


Items

Age

0 g/t

250g/t

3000g/t

IgA

(ng/mL)

21

7358.59±357.18B

9441.03±263.86A

9428.85±422.61A

42

7447.89±201.44C

9639.94±285.71B

10878.04±260.80A

IgG

(μg/mL)

21

72.06±0.75B

80.21±2.33A

79.03±2.38A

42

74.91±4.25B

92.87±3.31A

78.30±5.15B

IgM

(ng/mL)

21

3990.02±190.70B

4610.12±171.09A

4605.80±214.24A

42

4015.95±138.66B

5104.91±101.75A

4528.02±148.46B


HealGen


HealGen


Breeding effect —Improve the body's antioxidant capacity

HealGen significantly improves T-AOC, SOD and GSH-Px, reduces the level of MDA in broiler serum.


HealGen


Breeding effect — Effects on Clostridium perfringens challenge

HealGen could improve the performance of broilers and reduce the negative effects of C.p.


HealGen


HealGen


Test site: Hunan Agricultural University

Test animal: AA male broiler, 14-28d

Test design:

Control:basal diet

Test NH :basal diet+ 60 g/t HealGen

Test C.P :Control+ C.p challenge

Test NH+ C.p:Test NH+ C.p challenge

Challenge conditions: daily gavage of C.p suspension [1×109CFU/ (mL· only)]


Product Parameters


Product name

HealGen M100

HealGen NH

Identify ingredients

Muramidase, Mannanase

Muramidase, Xylanase, Mannanase, Cellulase, Glucanase

Dosage form

Soluble powder

Insoluble powder

Instructions

For drinking water, it is recommended to add 30g/t of water

It is recommended to add 250g/t of complete feed

Package

20kg/drum

25 kg/bag

Storage and Shelf Life

Store in a dry and ventilated place, avoid high temperature storage. Shelf life is 12 months in original packaging.




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